Vps25 | vacuolar protein sorting 25
Physiological systems
19 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Adipose tissue Embryo Growth/size/body region Mortality/aging Cardiovascular system
14 No significant impact
5 Not tested
Data collections
Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:42Adult tissues
29Embryo tissues
| decreased lean body mass | 1 supporting dataset | Vps25tm1.1(KOMP)Vlcg | heterozygote | Early adult | 6.6x10-5 | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Vps25tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Vps25tm1.1(KOMP)Vlcg | homozygote | E9.5 | N/A * | ||
| increased total body fat amount | 1 supporting dataset | Vps25tm1.1(KOMP)Vlcg | heterozygote | Early adult | 1.07x10-6 | ||
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Vps25tm1.1(KOMP)Vlcg | homozygote | E12.5 | N/A * | ||
| abnormal embryo size | 1 supporting dataset | Vps25tm1.1(KOMP)Vlcg | heterozygote | E9.5 | N/A * | ||
| decreased heart weight | 1 supporting dataset | Vps25tm1.1(KOMP)Vlcg | heterozygote | Early adult | 8.31x10-5 |
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| adrenal gland | heterozygote | n/a | 50% (1/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 50% (1/2) | 0.19% (1/533) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 100% (1/1) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 100% (2/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 100% (2/2) | 1.67% (7/419) |
| eye | heterozygote | n/a | 0% (0/2) | 0% (0/335) |
Human diseases caused by Vps25 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Vps25.
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| Vps25tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Vps25tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Vps25tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Vps25tm290428(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |
| Vps25tm47348(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |