Vcf1 | VCP nuclear cofactor family member 1
Physiological systems
19 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Growth/size/body region Hematopoietic system Behavior/neurological
14 No significant impact
5 Not tested
Data collections
Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| increased circulating bilirubin level | 1 supporting dataset | Vcf1tm2a(EUCOMM)Wtsi | homozygote | Early adult | 9.74x10-8 | ||
| decreased body weight | 1 supporting dataset | Vcf1tm2a(EUCOMM)Wtsi | homozygote | Early adult | 3.84x10-5 | ||
| abnormal behavior | 1 supporting dataset | Vcf1tm2a(EUCOMM)Wtsi | homozygote | Early adult | 4.52x10-5 | ||
| increased circulating alanine transaminase level | 1 supporting dataset | Vcf1tm2a(EUCOMM)Wtsi | homozygote | Early adult | 3.41x10-5 | ||
| increased lactate dehydrogenase level | 1 supporting dataset | Vcf1tm2a(EUCOMM)Wtsi | homozygote | Early adult | 1.22x10-7 | ||
| increased leukocyte cell number | 1 supporting dataset | Vcf1tm2a(EUCOMM)Wtsi | homozygote | Early adult | 2.82x10-7 | ||
| increased circulating aspartate transaminase level | 1 supporting dataset | Vcf1tm2a(EUCOMM)Wtsi | homozygote | Early adult | 5.43x10-10 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 50% (1/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | n/a | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | 0% (0/2) | 0% (0/173) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | n/a | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | n/a | 0.41% (2/491) |
Human diseases caused by Vcf1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Vcf1.
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| Vcf1tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Vcf1tm132(pL1L2_GT2_DelLacZ_bsd) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |
| Vcf1tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Vcf1tm2a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Vcf1tm2e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Vcf1tm3a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Vcf1tm3e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |