Nrp1 | neuropilin 1

GeneMGI:106206Synonyms: NP-1, Npn1, +2 more

Physiological systems

19 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Nervous system Hearing/vestibular/ear Mortality/aging

16 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:3Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



decreased prepulse inhibition	1 supporting dataset	Nrp1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.88x10^-5
abnormal auditory brainstem response	1 supporting dataset	Nrp1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	6.33x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Nrp1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Nrp1.

Associated images

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Histopathology

There is no histopathology data found for Nrp1.

IMPC related publications

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External links

No external links available for Nrp1.

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*Nrp1^{em1(IMPC)Ccpcz}*	Exon Deletion	‌	mouse
*Nrp1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Nrp1^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Nrp1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Nrp1^{tm2a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell

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