Loxl1 | lysyl oxidase-like 1
Physiological systems
17 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Nervous system Vision/eye Behavior/neurological
13 No significant impact
7 Not tested
Data collections
Gene metrics:5Significant phenotypes
1Associated diseases
Expression examined in:52Adult tissues
47Embryo tissues
| decreased circulating total protein level | 1 supporting dataset | Loxl1tm1.1(KOMP)Vlcg | homozygote | Early adult | 1.75x10-5 | ||
| increased fasting circulating glucose level | 1 supporting dataset | Loxl1tm1.1(KOMP)Vlcg | heterozygote | Early adult | 3.95x10-5 | ||
| abnormal retina morphology | 1 supporting dataset | Loxl1tm1.1(KOMP)Vlcg | homozygote | Early adult | 6.17x10-5 | ||
| abnormal sleep behavior | 2 supporting datasets | Loxl1tm1.1(KOMP)Vlcg | homozygote | Early adult | 1.52x10-8 | ||
| convulsive seizures | 1 supporting dataset | Loxl1tm1.1(KOMP)Vlcg | homozygote | Early adult | 7.1x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
Human diseases caused by Loxl1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Loxl1.
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