Cyp7a1 | cytochrome P450, family 7, subfamily a, polypeptide 1
Physiological systems
19 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Vision/eye Hematopoietic system Behavior/neurological Cardiovascular system
13 No significant impact
5 Not tested
Data collections
Gene metrics:18Significant phenotypes
1Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased circulating bilirubin level | 1 supporting dataset | Cyp7a1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 4.88x10-6 | ||
| increased circulating HDL cholesterol level | 1 supporting dataset | Cyp7a1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.69x10-9 | ||
| decreased exploration in new environment | 1 supporting dataset | Cyp7a1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.43x10-5 | ||
| abnormal lens morphology | 1 supporting dataset | Cyp7a1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 7.76x10-7 | ||
| abnormal retina vasculature morphology | 1 supporting dataset | Cyp7a1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.29x10-6 | ||
| abnormal retina morphology | 1 supporting dataset | Cyp7a1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.03x10-8 | ||
| increased startle reflex | 1 supporting dataset | Cyp7a1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 4.6x10-6 | ||
| increased circulating unsaturated transferrin level | 1 supporting dataset | Cyp7a1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 3.97x10-8 | ||
| decreased circulating iron level | 1 supporting dataset | Cyp7a1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 3.35x10-6 | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Cyp7a1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 5.08x10-12 |
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Human diseases caused by Cyp7a1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Cyp7a1.
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| Cyp7a1tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Cyp7a1tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Cyp7a1tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |