Ednra | endothelin receptor type A

GeneMGI:105923Synonyms: ETa, Gpcr10, +3 more

Physiological systems

20 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Growth/size/body region Vision/eye Mortality/aging Craniofacial

16 No significant impact

4 Not tested

Gene metrics:4Significant phenotypes
4Associated diseases
Expression examined in:48Adult tissues
25Embryo tissues

Phenotypes

cataract1 supporting datasetEdnratm1b(EUCOMM)HmguheterozygoteEarly adult2.78x10-5 
preweaning lethality, complete penetrance1 supporting datasetEdnratm1b(EUCOMM)HmguhomozygoteEarly adultN/A * 
abnormal craniofacial morphology1 supporting datasetEdnratm1b(EUCOMM)HmguhomozygoteE12.5N/A * 
abnormal facial morphology1 supporting datasetEdnratm1b(EUCOMM)HmguhomozygoteE18.5N/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Ednratm1(NCOM)MfgcReporter-tagged deletion allele (with selection cassette)targeting vector
es cell
Ednratm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
mouse
Ednratm1b(EUCOMM)HmguReporter-tagged deletion allele (with selection cassette)mouse

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