Nin | ninein
Physiological systems
17 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Nervous system Hearing/vestibular/ear Behavior/neurological
14 No significant impact
7 Not tested
Data collections
Gene metrics:5Significant phenotypes
2Associated diseases
Expression examined in:152Adult tissues
50Embryo tissues
| abnormal auditory brainstem response | 5 supporting datasets | Nintm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.48x10-6 | ||
| decreased prepulse inhibition | 5 supporting datasets | Nintm1b(EUCOMM)Hmgu | homozygote | Early adult | 7.36x10-34 | ||
| hyperactivity | 9 supporting datasets | Nintm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.75x10-13 | ||
| decreased anxiety-related response | 1 supporting dataset | Nintm1b(EUCOMM)Hmgu | homozygote | Early adult | 5.35x10-9 | ||
| decreased startle reflex | 1 supporting dataset | Nintm1b(EUCOMM)Hmgu | homozygote | Early adult | 4.91x10-9 |
| | | | | | | | | | |
| adrenal gland | heterozygote | Wholemount images | n/a | 0.7% (4/570) |
| adrenal gland | homozygote | Wholemount images | n/a | 0.7% (4/570) |
| aorta | homozygote | Wholemount images | 100% (2/2) | 0.19% (1/533) |
| aorta | heterozygote | Wholemount images | n/a | 0.19% (1/533) |
| bone | heterozygote | Wholemount images | n/a | 0% (0/394) |
| bone | homozygote | Wholemount images | 100% (2/2) | 0% (0/394) |
| brain | homozygote | Wholemount images | 100% (2/2) | 0.86% (5/579) |
| brain | heterozygote | Wholemount images | 100% (4/4) | 0.86% (5/579) |
| brainstem | homozygote | n/a | 100% (2/2) | 0.41% (2/490) |
| brainstem | heterozygote | n/a | 100% (4/4) | 0.41% (2/490) |
Human diseases caused by Nin mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Nin.
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| Nintm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Nintm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Nintm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |