Hsd17b4 | hydroxysteroid (17-beta) dehydrogenase 4

GeneMGI:105089Synonyms: D-bifunctional protein, Mfp-2, +5 more

Physiological systems

21 / 24 physiological systems tested

15 Significantly impacted by the knock-out

Reproductive system Immune system Endocrine/exocrine gland Growth/size/body region Hearing/vestibular/ear Hematopoietic system Craniofacial Cardiovascular system Renal/urinary system Homeostasis/metabolism Embryo Vision/eye Behavior/neurological Skeleton Mortality/aging

6 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:24Significant phenotypes

5Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal seminal vesicle morphology	1 supporting dataset	Hsd17b4^em1(IMPC)Tcp	heterozygote	Late adult	N/A ^*
limb grasping	1 supporting dataset	Hsd17b4^em1(IMPC)Tcp	homozygote	Early adult	1.28x10^-8
abnormal gait	1 supporting dataset	Hsd17b4^em1(IMPC)Tcp	homozygote	Early adult	1.28x10^-8
abnormal sternum morphology	1 supporting dataset	Hsd17b4^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
small uterus	1 supporting dataset	Hsd17b4^em1(IMPC)Tcp	heterozygote	Late adult	N/A ^*
abnormal iris morphology	1 supporting dataset	Hsd17b4^em1(IMPC)Tcp	homozygote	Early adult	1.55x10^-5
abnormal tooth morphology	1 supporting dataset	Hsd17b4^em1(IMPC)Tcp	homozygote	Early adult	8.26x10^-7
abnormal eye morphology	1 supporting dataset	Hsd17b4^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
preweaning lethality, incomplete penetrance	3 supporting datasets	Hsd17b4^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
enlarged adrenal glands	1 supporting dataset	Hsd17b4^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Hsd17b4.

Associated images

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Histopathology

There is no histopathology data found for Hsd17b4.

IMPC related publications

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External links

No external links available for Hsd17b4.

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*Hsd17b4^em1(IMPC)Tcp*	Indel	‌	mouse
*Hsd17b4^{tm40163(L1L2_gt1)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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