Hsd17b4 | hydroxysteroid (17-beta) dehydrogenase 4

GeneMGI:105089Synonyms: D-bifunctional protein, Mfp-2, +5 more

Physiological systems

21 / 24 physiological systems tested

15 Significantly impacted by the knock-out

Reproductive system Immune system Endocrine/exocrine gland Growth/size/body region Hearing/vestibular/ear Hematopoietic system Craniofacial Cardiovascular system Renal/urinary system Homeostasis/metabolism Embryo Vision/eye Behavior/neurological Skeleton Mortality/aging

6 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:24Significant phenotypes

5Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal seminal vesicle morphology	1 supporting dataset	Hsd17b4^em1(IMPC)Tcp	heterozygote	Late adult	N/A ^*
limb grasping	1 supporting dataset	Hsd17b4^em1(IMPC)Tcp	homozygote	Early adult	1.28x10^-8
abnormal gait	1 supporting dataset	Hsd17b4^em1(IMPC)Tcp	homozygote	Early adult	1.28x10^-8
abnormal sternum morphology	1 supporting dataset	Hsd17b4^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
small uterus	1 supporting dataset	Hsd17b4^em1(IMPC)Tcp	heterozygote	Late adult	N/A ^*
abnormal iris morphology	1 supporting dataset	Hsd17b4^em1(IMPC)Tcp	homozygote	Early adult	1.55x10^-5
abnormal tooth morphology	1 supporting dataset	Hsd17b4^em1(IMPC)Tcp	homozygote	Early adult	8.26x10^-7
abnormal eye morphology	1 supporting dataset	Hsd17b4^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
preweaning lethality, incomplete penetrance	3 supporting datasets	Hsd17b4^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
enlarged adrenal glands	1 supporting dataset	Hsd17b4^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Hsd17b4.

Associated images

1 images

Combined SHIRPA and Dysmorphology

Images

57 images

Eye Morphology

Images Ophthalmoscopy

25 images

Eye Morphology

Images Slit Lamp

4 images

Gross Morphology Embryo E18.5

Images

7 images

Gross Pathology and Tissue Collection

Images

12 images

Histopathology

Images

Download files

Immunophenotyping

Panel A FCS file(s)

Download files

Immunophenotyping

Panel B FCS file(s)

View on Embryo Viewer

MicroCT E18.5

Embryo reconstruction

15 images

X-ray

XRay Images Skull Dorso Ventral Orientation

10 images

X-ray

XRay Images Skull Lateral Orientation

10 images

X-ray

XRay Images Whole Body Dorso Ventral

10 images

X-ray

XRay Images Whole Body Lateral Orientation

Histopathology

This gene doesn't have any significant Histopathology hits. Click here to see the raw data

IMPC related publications

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External links

No external links available for Hsd17b4.

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*Hsd17b4^em1(IMPC)Tcp*	Indel	‌	mouse
*Hsd17b4^{tm40163(L1L2_gt1)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

My Genes

Hsd17b4 | hydroxysteroid (17-beta) dehydrogenase 4

Physiological systems

15 Significantly impacted by the knock-out

6 No significant impact

3 Not tested

Data collections

Phenotypes

lacZ Expression

Associated images

Combined SHIRPA and Dysmorphology

Eye Morphology

Eye Morphology

Gross Morphology Embryo E18.5

Gross Pathology and Tissue Collection

Histopathology

Immunophenotyping

Immunophenotyping

MicroCT E18.5

X-ray

X-ray

X-ray

X-ray

Histopathology

IMPC related publications

External links

Order Mouse and ES Cells

The IMPC Newsletter

Access Data Release 22.1 Data