Rbl2 | RB transcriptional corepressor like 2
Physiological systems
17 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Homeostasis/metabolism Vision/eye Mortality/aging
14 No significant impact
7 Not tested
Data collections
Gene metrics:5Significant phenotypes
1Associated diseases
Expression examined in:49Adult tissues
50Embryo tissues
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Rbl2tm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| increased circulating HDL cholesterol level | 1 supporting dataset | Rbl2tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 6.39x10-6 | ||
| abnormal retina morphology | 1 supporting dataset | Rbl2tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 1.79x10-5 | ||
| persistence of hyaloid vascular system | 1 supporting dataset | Rbl2tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 2.24x10-5 | ||
| increased circulating cholesterol level | 1 supporting dataset | Rbl2tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 5.24x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 100% (2/2) | 0.19% (1/533) |
| bone | heterozygote | Section images | 100% (2/2) | 0% (0/394) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images | 100% (2/2) | 0% (0/588) |
| cartilage tissue | heterozygote | Section images | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Section images | 100% (2/2) | 0.41% (2/491) |
| epididymis | heterozygote | Section images | 100% (1/1) | 87.5% (21/24) |
Human diseases caused by Rbl2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Rbl2.
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| Rbl2tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Rbl2tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |