Rest | RE1-silencing transcription factor
Physiological systems
18 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Hearing/vestibular/ear Hematopoietic system Cardiovascular system Mortality/aging
14 No significant impact
6 Not tested
Data collections
Gene metrics:4Significant phenotypes
5Associated diseases
Expression examined in:70Adult tissues
0Embryo tissues
| decreased mean platelet volume | 1 supporting dataset | Resttm2b(EUCOMM)Wtsi | heterozygote | Early adult | 8.51x10-5 | ||
| decreased heart rate | 1 supporting dataset | Resttm2b(EUCOMM)Wtsi | heterozygote | Early adult | 8.19x10-5 | ||
| abnormal auditory brainstem response | 1 supporting dataset | Resttm2b(EUCOMM)Wtsi | heterozygote | Early adult | 2.35x10-5 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Resttm2b(EUCOMM)Wtsi | homozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | Wholemount images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/2) | 7.75% (22/284) |
Human diseases caused by Rest mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Rest.
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| Resttm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Resttm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Resttm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Resttm2a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Resttm2b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Resttm2e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Resttm47385(L1L2_gt0) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |