Fgf9 | fibroblast growth factor 9
Physiological systems
22 / 24 physiological systems tested
10 Significantly impacted by the knock-out
Immune system Embryo Growth/size/body region Digestive/alimentary Vision/eye Hematopoietic system Behavior/neurological Cardiovascular system Mortality/aging Craniofacial
12 No significant impact
2 Not tested
Gene metrics:10Significant phenotypes
2Associated diseases
Expression examined in:52Adult tissues
48Embryo tissues
| cataract | 1 supporting dataset | Fgf9tm1b(KOMP)Wtsi | heterozygote | Early adult | 6.92x10-17 | ||
| abnormal retina vasculature morphology | 1 supporting dataset | Fgf9tm1b(KOMP)Wtsi | heterozygote | Early adult | 4.51x10-20 | ||
| hyperactivity | 4 supporting datasets | Fgf9tm1b(KOMP)Wtsi | heterozygote | Early adult | 5.09x10-6 | ||
| abnormal embryo size | 1 supporting dataset | Fgf9tm1b(KOMP)Wtsi | homozygote | E18.5 | N/A * | ||
| abnormal body wall morphology | 1 supporting dataset | Fgf9tm1b(KOMP)Wtsi | homozygote | E18.5 | N/A * | ||
| preweaning lethality, complete penetrance | 2 supporting datasets | Fgf9tm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| cleft palate | 1 supporting dataset | Fgf9tm1b(KOMP)Wtsi | homozygote | E18.5 | N/A * | ||
| increased heart weight | 1 supporting dataset | Fgf9tm1b(KOMP)Wtsi | heterozygote | Early adult | 4x10-6 | ||
| decreased spleen weight | 1 supporting dataset | Fgf9tm1b(KOMP)Wtsi | heterozygote | Early adult | 8.67x10-5 | ||
| enlarged heart | 1 supporting dataset | Fgf9tm1b(KOMP)Wtsi | heterozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 50% (2/4) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/4) | 0.19% (1/533) |
| bone | heterozygote | n/a | 100% (2/2) | 0% (0/394) |
| brain | heterozygote | Section images | 100% (4/4) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 100% (4/4) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/4) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 50% (2/4) | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 100% (4/4) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 50% (2/4) | 0.41% (2/491) |
| epididymis | heterozygote | n/a | 0% (0/1) | 87.5% (21/24) |
Human diseases caused by Fgf9 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Fgf9.
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| Fgf9tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Fgf9tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Fgf9tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |