Fgf9 | fibroblast growth factor 9

GeneMGI:104723Synonyms: Eks, glia activating factor

Physiological systems

22 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Immune system Embryo Growth/size/body region Digestive/alimentary Vision/eye Hematopoietic system Behavior/neurological Cardiovascular system Mortality/aging Craniofacial

12 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

2Associated diseases

Expression examined in:52Adult tissues

48Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



cataract	1 supporting dataset	Fgf9^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	6.92x10^-17
abnormal retina vasculature morphology	1 supporting dataset	Fgf9^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	4.51x10^-20
hyperactivity	4 supporting datasets	Fgf9^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	5.09x10^-6
abnormal embryo size	1 supporting dataset	Fgf9^{tm1b(KOMP)Wtsi}	homozygote	E18.5	N/A ^*
abnormal body wall morphology	1 supporting dataset	Fgf9^{tm1b(KOMP)Wtsi}	homozygote	E18.5	N/A ^*
preweaning lethality, complete penetrance	2 supporting datasets	Fgf9^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
cleft palate	1 supporting dataset	Fgf9^{tm1b(KOMP)Wtsi}	homozygote	E18.5	N/A ^*
increased heart weight	1 supporting dataset	Fgf9^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	4x10^-6
decreased spleen weight	1 supporting dataset	Fgf9^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	8.67x10^-5
enlarged heart	1 supporting dataset	Fgf9^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Fgf9.

Associated images

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Histopathology

There is no histopathology data found for Fgf9.

IMPC related publications

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External links

No external links available for Fgf9.

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*Fgf9^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Fgf9^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Fgf9^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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