Wbp2 | WW domain binding protein 2
GeneMGI:104709
Physiological systems
20 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Immune system Hematopoietic system Behavior/neurological
17 No significant impact
4 Not tested
Data collections
Gene metrics:8Significant phenotypes
2Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| increased startle reflex | 4 supporting datasets | Wbp2tm2a(EUCOMM)Wtsi | homozygote | Early adult | 2.97x10-8 | ||
| abnormal behavior | 3 supporting datasets | Wbp2tm2a(EUCOMM)Wtsi | homozygote | Early adult | 1.46x10-9 | ||
| decreased hematocrit | 1 supporting dataset | Wbp2tm2a(EUCOMM)Wtsi | homozygote | Early adult | 2.51x10-7 | ||
| hyperactivity | 2 supporting datasets | Wbp2tm2a(EUCOMM)Wtsi | homozygote | Early adult | 4.85x10-10 | ||
| decreased erythrocyte cell number | 1 supporting dataset | Wbp2tm2a(EUCOMM)Wtsi | homozygote | Early adult | 3.32x10-8 | ||
| increased leukocyte cell number | 1 supporting dataset | Wbp2tm2a(EUCOMM)Wtsi | homozygote | Early adult | 3.9x10-5 | ||
| absent pinna reflex | 1 supporting dataset | Wbp2tm2a(EUCOMM)Wtsi | homozygote | Early adult | 9.35x10-8 | ||
| decreased hemoglobin content | 1 supporting dataset | Wbp2tm2a(EUCOMM)Wtsi | homozygote | Early adult | 5.33x10-7 |
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| adrenal gland | heterozygote | n/a | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | n/a | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | 100% (2/2) | 0% (0/173) |
| bone | heterozygote | n/a | 100% (2/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 100% (2/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | n/a | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | n/a | 0.41% (2/491) |
Human diseases caused by Wbp2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Wbp2.
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| Wbp2tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Wbp2tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Wbp2tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Wbp2tm2a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |