Dll1 | delta like canonical Notch ligand 1

GeneMGI:104659Synonyms: Delta1

Physiological systems

18 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Growth/size/body region Digestive/alimentary Vision/eye Respiratory system Hematopoietic system Behavior/neurological

10 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:27Significant phenotypes

8Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Allele:

Phy. System:



increased lymphocyte cell number	1 supporting dataset	Dll1^tm1Gos	heterozygote	Early adult	3.45x10^-10
abnormal whole-body plethysmography	9 supporting datasets	Dll1^tm1Gos	heterozygote	Early adult	4.72x10^-7
decreased circulating triglyceride level	1 supporting dataset	Dll1^m1Mhda	heterozygote	Early adult	1.02x10^-6
increased blood urea nitrogen level	1 supporting dataset	Dll1^m1Mhda	heterozygote	Early adult	1.04x10^-10
decreased body weight	7 supporting datasets	Dll1^tm1Gos	heterozygote	Early adult	6.19x10^-17
abnormal anxiety-related response	1 supporting dataset	Dll1^tm1Gos	heterozygote	Early adult	5.25x10^-8
decreased circulating cholesterol level	1 supporting dataset	Dll1^tm1Gos	heterozygote	Early adult	1.38x10^-8
decreased circulating chloride level	1 supporting dataset	Dll1^tm1Gos	heterozygote	Early adult	1.66x10^-10
increased hemoglobin content	1 supporting dataset	Dll1^tm1Gos	heterozygote	Early adult	1.3x10^-11
decreased circulating calcium level	1 supporting dataset	Dll1^tm1Gos	heterozygote	Early adult	8.83x10^-11

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Dll1.

Associated images

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Histopathology

There is no histopathology data found for Dll1.

IMPC related publications

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External links

No external links available for Dll1.

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*Dll1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Dll1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Dll1^{tm40146(L1L2_st1)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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