Tgfbr3 | transforming growth factor, beta receptor III

GeneMGI:104637Synonyms: 1110036H20Rik, TBRIII, +1 more

Physiological systems

22 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Embryo Growth/size/body region Vision/eye Liver/biliary system Mortality/aging Cardiovascular system Renal/urinary system

14 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



preweaning lethality, complete penetrance	3 supporting datasets	Tgfbr3^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
edema	1 supporting dataset	Tgfbr3^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
embryonic growth retardation	1 supporting dataset	Tgfbr3^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
abnormal placenta vasculature	1 supporting dataset	Tgfbr3^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
abnormal placenta morphology	1 supporting dataset	Tgfbr3^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
abnormal placenta morphology	1 supporting dataset	Tgfbr3^em1(IMPC)Mbp	heterozygote	E15.5	N/A ^*
microphthalmia	1 supporting dataset	Tgfbr3^em1(IMPC)Mbp	heterozygote	E15.5	N/A ^*
abnormal placenta vasculature	1 supporting dataset	Tgfbr3^em1(IMPC)Mbp	heterozygote	E15.5	N/A ^*
enlarged kidney	1 supporting dataset	Tgfbr3^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
pale liver	1 supporting dataset	Tgfbr3^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Tgfbr3.

Associated images

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Histopathology

There is no histopathology data found for Tgfbr3.

IMPC related publications

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External links

No external links available for Tgfbr3.

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*Tgfbr3^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Tgfbr3^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Tgfbr3^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Tgfbr3^{tm46129(L1L2_st0)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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