Rab34 | RAB34, member RAS oncogene family
Physiological systems
21 / 24 physiological systems tested
9 Significantly impacted by the knock-out
Homeostasis/metabolism Embryo Growth/size/body region Limbs/digits/tail Digestive/alimentary Vision/eye Craniofacial Mortality/aging Cardiovascular system
12 No significant impact
3 Not tested
Gene metrics:12Significant phenotypes
1Associated diseases
Expression examined in:48Adult tissues
50Embryo tissues
| edema | 1 supporting dataset | Rab34tm1b(EUCOMM)Hmgu | homozygote | E12.5 | N/A * | ||
| polydactyly | 1 supporting dataset | Rab34tm1b(EUCOMM)Hmgu | homozygote | E18.5 | N/A * | ||
| increased heart weight | 1 supporting dataset | Rab34tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 5.89x10-5 | ||
| cleft palate | 1 supporting dataset | Rab34tm1b(EUCOMM)Hmgu | homozygote | E15.5 | N/A * | ||
| anophthalmia | 1 supporting dataset | Rab34tm1b(EUCOMM)Hmgu | homozygote | E15.5 | N/A * | ||
| abnormal limb morphology | 1 supporting dataset | Rab34tm1b(EUCOMM)Hmgu | homozygote | E18.5 | N/A * | ||
| abnormal limb bud morphology | 1 supporting dataset | Rab34tm1b(EUCOMM)Hmgu | homozygote | E12.5 | N/A * | ||
| facial cleft | 1 supporting dataset | Rab34tm1b(EUCOMM)Hmgu | homozygote | E18.5 | N/A * | ||
| polydactyly | 1 supporting dataset | Rab34tm1b(EUCOMM)Hmgu | homozygote | E15.5 | N/A * | ||
| edema | 1 supporting dataset | Rab34tm1b(EUCOMM)Hmgu | homozygote | E15.5 | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 100% (2/2) | 0.19% (1/533) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | Section images | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Section images | 100% (2/2) | 0.41% (2/491) |
| epididymis | heterozygote | Section images | 100% (1/1) | 87.5% (21/24) |
| esophagus | heterozygote | Section images | 100% (2/2) | 1.67% (7/419) |
Human diseases caused by Rab34 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Rab34.
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| Rab34tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Rab34tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Rab34tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Rab34tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |