Rcn1 | reticulocalbin 1

GeneMGI:104559Synonyms: Rcn

Physiological systems

19 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Homeostasis/metabolism Limbs/digits/tail Vision/eye Skeleton Cardiovascular system

14 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:9Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

increased circulating alkaline phosphatase level1 supporting datasetRcn1tm1b(EUCOMM)HmguhomozygoteEarly adult2.03x10-10 
persistence of hyaloid vascular system1 supporting datasetRcn1tm1b(EUCOMM)HmguhomozygoteEarly adult8.54x10-6 
abnormal retina vasculature morphology1 supporting datasetRcn1tm1b(EUCOMM)HmguhomozygoteEarly adult6.24x10-10 
abnormal retina morphology1 supporting datasetRcn1tm1b(EUCOMM)HmguhomozygoteEarly adult2.13x10-7 
short tibia1 supporting datasetRcn1tm1b(EUCOMM)HmguhomozygoteEarly adult6.89x10-6 
abnormal lens morphology1 supporting datasetRcn1tm1b(EUCOMM)HmguhomozygoteEarly adult2.4x10-5 
abnormal retina blood vessel morphology1 supporting datasetRcn1tm1b(EUCOMM)HmguhomozygoteEarly adult6.59x10-9 
decreased blood urea nitrogen level1 supporting datasetRcn1tm1b(EUCOMM)HmguhomozygoteEarly adult8.61x10-5 
cataract1 supporting datasetRcn1tm1b(EUCOMM)HmguhomozygoteEarly adult6.77x10-6 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Rcn1tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
Rcn1tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Rcn1tm1b(EUCOMM)HmguReporter-tagged deletion allele (with selection cassette)mouse
Rcn1tm40194(L1L2_gt1)KO first allele (reporter-tagged insertion with conditional potential)targeting vector
Rcn1tm40194(L1L2_st1)KO first allele (reporter-tagged insertion with conditional potential)targeting vector
Rcn1tm40194(L1L2_st2)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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