Rcn1 | reticulocalbin 1
Physiological systems
19 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Limbs/digits/tail Vision/eye Skeleton Cardiovascular system
14 No significant impact
5 Not tested
Data collections
Gene metrics:9Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased circulating alkaline phosphatase level | 1 supporting dataset | Rcn1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 2.03x10-10 | ||
| persistence of hyaloid vascular system | 1 supporting dataset | Rcn1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 8.54x10-6 | ||
| abnormal retina vasculature morphology | 1 supporting dataset | Rcn1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 6.24x10-10 | ||
| abnormal retina morphology | 1 supporting dataset | Rcn1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 2.13x10-7 | ||
| short tibia | 1 supporting dataset | Rcn1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 6.89x10-6 | ||
| abnormal lens morphology | 1 supporting dataset | Rcn1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 2.4x10-5 | ||
| abnormal retina blood vessel morphology | 1 supporting dataset | Rcn1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 6.59x10-9 | ||
| decreased blood urea nitrogen level | 1 supporting dataset | Rcn1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 8.61x10-5 | ||
| cataract | 1 supporting dataset | Rcn1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 6.77x10-6 |
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Human diseases caused by Rcn1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Rcn1.
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| Rcn1tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Rcn1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Rcn1tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Rcn1tm40194(L1L2_gt1) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |
| Rcn1tm40194(L1L2_st1) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |
| Rcn1tm40194(L1L2_st2) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |