Nog | noggin

Physiological systems

22 / 24 physiological systems tested

11 Significantly impacted by the knock-out

 Homeostasis/metabolism Embryo Growth/size/body region Limbs/digits/tail Nervous system Vision/eye Skeleton Mortality/aging Cardiovascular system Craniofacial Renal/urinary system

11 No significant impact

2 Not tested

Gene metrics:21Significant phenotypes
10Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

abnormal visceral yolk sac morphology1 supporting datasetNogem1(IMPC)MbphomozygoteE9.5N/A * 
abnormal snout morphology1 supporting datasetNogem1(IMPC)MbpheterozygoteEarly adult4.56x10-8 
abnormal heart morphology1 supporting datasetNogem1(IMPC)MbphomozygoteE9.5N/A * 
abnormal neural tube closure1 supporting datasetNogem1(IMPC)MbphomozygoteE9.5N/A * 
preweaning lethality, complete penetrance3 supporting datasetsNogem1(IMPC)MbphomozygoteEarly adultN/A * 
abnormal somite shape1 supporting datasetNogem1(IMPC)MbphomozygoteE9.5N/A * 
embryonic growth retardation1 supporting datasetNogem1(IMPC)MbphomozygoteE9.5N/A * 
small kidney1 supporting datasetNogem1(IMPC)MbpheterozygoteEarly adultN/A * 
abnormal bone structure1 supporting datasetNogem1(IMPC)MbpheterozygoteEarly adult3.36x10-11 
abnormal neural tube morphology1 supporting datasetNogem1(IMPC)MbphomozygoteE9.5N/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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