Sox18 | SRY (sex determining region Y)-box 18
Physiological systems
17 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Homeostasis/metabolism Hematopoietic system Behavior/neurological
14 No significant impact
7 Not tested
Data collections
Gene metrics:5Significant phenotypes
3Associated diseases
Expression examined in:49Adult tissues
51Embryo tissues
| decreased thigmotaxis | 2 supporting datasets | Sox18tm1.1(KOMP)Vlcg | homozygote | Early adult | 2.5x10-6 | ||
| increased circulating sodium level | 1 supporting dataset | Sox18tm1.1(KOMP)Vlcg | homozygote | Early adult | 9.6x10-5 | ||
| abnormal behavior | 1 supporting dataset | Sox18tm1.1(KOMP)Vlcg | homozygote | Early adult | 2.5x10-6 | ||
| increased mean corpuscular hemoglobin | 1 supporting dataset | Sox18tm1.1(KOMP)Vlcg | homozygote | Early adult | 7.47x10-5 | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Sox18tm1.1(KOMP)Vlcg | homozygote | Early adult | 8.82x10-7 |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 100% (2/2) | 0.19% (1/533) |
| bone marrow | heterozygote | Section images | 100% (2/2) | 0% (0/22) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images | 100% (2/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Section images | 100% (2/2) | 0.41% (2/491) |
| epididymis | heterozygote | Section images | 100% (1/1) | 87.5% (21/24) |
Human diseases caused by Sox18 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Sox18.
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