Scn8a | sodium channel, voltage-gated, type VIII, alpha

GeneMGI:103169Synonyms: ataxia 3, seal, +12 more

Physiological systems

19 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Immune system Growth/size/body region Hematopoietic system Mortality/aging

15 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:2Significant phenotypes

8Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



increased spleen weight	1 supporting dataset	Scn8a^em1(IMPC)Bay	heterozygote	Early adult	1.87x10^-5
preweaning lethality, incomplete penetrance	3 supporting datasets	Scn8a^em1(IMPC)Bay	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Scn8a.

Associated images

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Histopathology

There is no histopathology data found for Scn8a.

IMPC related publications

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External links

No external links available for Scn8a.

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*Scn8a^em1(IMPC)Bay*	Exon Deletion	‌	mouse
*Scn8a^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Scn8a^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Scn8a^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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