Cish | cytokine inducible SH2-containing protein
Physiological systems
20 / 24 physiological systems tested
1 Significantly impacted by the knock-out
Homeostasis/metabolism
19 No significant impact
4 Not tested
Data collections
Gene metrics:1Significant phenotypes
3Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| increased circulating chloride level | 1 supporting dataset | Cishtm1a(KOMP)Wtsi | homozygote | Early adult | 6.02x10-8 |
| | | | | | | | | | |
| adrenal gland | homozygote | n/a | 100% (2/2) | 0.7% (4/570) |
| aorta | homozygote | n/a | n/a | 0.19% (1/533) |
| blood vessel | homozygote | n/a | 100% (2/2) | 0% (0/173) |
| bone | homozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | homozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | homozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | homozygote | n/a | 100% (2/2) | 0% (0/588) |
| cartilage tissue | homozygote | n/a | 100% (2/2) | 0.22% (1/454) |
| cerebellum | homozygote | n/a | n/a | 0.56% (3/532) |
| cerebral cortex | homozygote | n/a | n/a | 0.41% (2/491) |
Human diseases caused by Cish mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Cish.
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| Cishtm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Cishtm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Cishtm2a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |