Dnase1 | deoxyribonuclease I

GeneMGI:103157Synonyms: Dnl1, DNaseI

Physiological systems

18 / 24 physiological systems tested

2 Significantly impacted by the knock-out

Hearing/vestibular/ear Renal/urinary system

16 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:2Significant phenotypes

3Associated diseases

Expression examined in:73Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal urinary bladder morphology	1 supporting dataset	Dnase1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
abnormal auditory brainstem response	2 supporting datasets	Dnase1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	3.73x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Dnase1.

Associated images

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Histopathology

There is no histopathology data found for Dnase1.

IMPC related publications

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External links

No external links available for Dnase1.

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*Dnase1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Dnase1^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Dnase1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Dnase1^{tm214458(L1L2_Bact_P)}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector

My Genes