Ube2b | ubiquitin-conjugating enzyme E2B

GeneMGI:102944Synonyms: E2-14k, HR6B, +1 more

Physiological systems

22 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Integument Growth/size/body region Hematopoietic system Behavior/neurological Cardiovascular system Mortality/aging

14 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:14Significant phenotypes

0Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:



preweaning lethality, complete penetrance	1 supporting dataset	Ube2b^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
limb grasping	1 supporting dataset	Ube2b^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	9.41x10^-7
increased lymphocyte cell number	2 supporting datasets	Ube2b^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	2.3x10^-5
increased leukocyte cell number	1 supporting dataset	Ube2b^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	4.35x10^-5
abnormal behavior	1 supporting dataset	Ube2b^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	4.51x10^-7
decreased neutrophil cell number	1 supporting dataset	Ube2b^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	2.68x10^-5
abnormal coat appearance	1 supporting dataset	Ube2b^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	7.06x10^-6
increased circulating phosphate level	1 supporting dataset	Ube2b^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	5.2x10^-5
increased circulating alkaline phosphatase level	1 supporting dataset	Ube2b^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	4.35x10^-5
enlarged heart	2 supporting datasets	Ube2b^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ube2b.

Associated images

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Histopathology

There is no histopathology data found for Ube2b.

IMPC related publications

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External links

No external links available for Ube2b.

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*Ube2b^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Ube2b^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Ube2b^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

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