Six1 | sine oculis-related homeobox 1
GeneMGI:102780
Physiological systems
22 / 24 physiological systems tested
14 Significantly impacted by the knock-out
Reproductive system Immune system Integument Growth/size/body region Digestive/alimentary Hematopoietic system Cardiovascular system Craniofacial Renal/urinary system Homeostasis/metabolism Embryo Nervous system Vision/eye Mortality/aging
8 No significant impact
2 Not tested
Data collections
Gene metrics:23Significant phenotypes
5Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal placenta morphology | 1 supporting dataset | Six1em1(IMPC)Mbp | heterozygote | E15.5 | N/A * | ||
| abnormal skin morphology | 1 supporting dataset | Six1em1(IMPC)Mbp | heterozygote | Late adult | N/A * | ||
| abnormal skin morphology | 1 supporting dataset | Six1em1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Six1em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| enlarged spleen | 2 supporting datasets | Six1em1(IMPC)Mbp | heterozygote | Late adult | N/A * | ||
| decreased prepulse inhibition | 2 supporting datasets | Six1em1(IMPC)Mbp | heterozygote | Early adult | 3.25x10-8 | ||
| abnormal spleen morphology | 2 supporting datasets | Six1em1(IMPC)Mbp | heterozygote | Late adult | N/A * | ||
| abnormal retina morphology | 1 supporting dataset | Six1em1(IMPC)Mbp | heterozygote | Early adult | 5.03x10-5 | ||
| decreased circulating calcium level | 1 supporting dataset | Six1em1(IMPC)Mbp | heterozygote | Early adult | 4.8x10-5 | ||
| abnormal blood vessel morphology | 1 supporting dataset | Six1em1(IMPC)Mbp | heterozygote | E15.5 | N/A * |
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External links
No external links available for Six1.
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| Six1em1(IMPC)Mbp | Whole-gene deletion | | mouse |