Dct | dopachrome tautomerase

GeneMGI:102563Synonyms: TRP-2, Tyrp2, +3 more

Physiological systems

21 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Homeostasis/metabolism Pigmentation Integument

18 No significant impact

3 Not tested

Gene metrics:4Significant phenotypes
2Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues

Phenotypes

abnormal skin morphology2 supporting datasetsDcttm1b(KOMP)MbphomozygoteEarly adultN/A * 
abnormal coat/hair pigmentation3 supporting datasetsDcttm1b(KOMP)MbphomozygoteEarly adult1.05x10-17 
increased circulating bilirubin level1 supporting datasetDcttm1b(KOMP)MbphomozygoteEarly adult1.69x10-5 
increased circulating phosphate level1 supporting datasetDcttm1b(KOMP)MbphomozygoteEarly adult2.53x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Dcttm1a(KOMP)MbpKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Dcttm1b(KOMP)MbpReporter-tagged deletion allele (with selection cassette)mouse
Dcttm1e(KOMP)MbpTargeted, non-conditional alleleES Cell
Dcttm1e(KOMP)WtsiTargeted, non-conditional alleleES Cell
Dcttm2a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Dcttm2e(KOMP)WtsiTargeted, non-conditional alleleES Cell

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