Tead1 | TEA domain family member 1
Physiological systems
21 / 24 physiological systems tested
9 Significantly impacted by the knock-out
Homeostasis/metabolism Adipose tissue Embryo Growth/size/body region Nervous system Vision/eye Skeleton Mortality/aging Craniofacial
12 No significant impact
3 Not tested
Gene metrics:11Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
62Embryo tissues
| preweaning lethality, complete penetrance | 3 supporting datasets | Tead1tm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| abnormal tooth morphology | 1 supporting dataset | Tead1tm1b(KOMP)Wtsi | heterozygote | Early adult | 5.86x10-5 | ||
| abnormal embryo turning | 1 supporting dataset | Tead1tm1b(KOMP)Wtsi | homozygote | E9.5 | N/A * | ||
| abnormal retina morphology | 1 supporting dataset | Tead1tm1a(KOMP)Wtsi | heterozygote | Early adult | 1.03x10-7 | ||
| decreased prepulse inhibition | 1 supporting dataset | Tead1tm1b(KOMP)Wtsi | heterozygote | Early adult | 1.12x10-7 | ||
| decreased cornea thickness | 2 supporting datasets | Tead1tm1b(KOMP)Wtsi | heterozygote | Early adult | 4.93x10-8 | ||
| abnormal embryo size | 1 supporting dataset | Tead1tm1b(KOMP)Wtsi | homozygote | E9.5 | N/A * | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Tead1tm1a(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| abnormal eye anterior chamber depth | 1 supporting dataset | Tead1tm1b(KOMP)Wtsi | heterozygote | Early adult | 4.03x10-5 | ||
| increased total body fat amount | 2 supporting datasets | Tead1tm1b(KOMP)Wtsi | heterozygote | Early adult | 3.87x10-6 |
| | | | | | | | | | |
Human diseases caused by Tead1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Tead1.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Tead1tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Tead1tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |