The International Knockout Mouse Consortium (IKMC) is a scientific endeavour to produce a collection of mouse lines, each lacking a protein-coding gene, using a combination of gene trapping and gene targeting in C57BL/6 mouse embryonic stem (ES) cells.
The IKMC includes the following programs:
- Knockout Mouse Project (KOMP) (USA):
- CSD, a collaborative team at the Children’s Hospital Oakland Research Institute (CHORI), the University of California at Davis School of Veterinary Medicine, led by Pieter deJong, Ph.D., CHORI, along with K. C. Kent Lloyd, D.V.M., Ph.D., UC Davis; and Allan Bradley, Ph.D. FRS, and William Skarnes, Ph.D., at the Wellcome Trust Sanger Institute .
- Regeneron, a team at the VelociGene division of Regeneron Pharmaceuticals, Inc., led by David Valenzuela, Ph.D. and George D. Yancopoulos, M.D., Ph.D.
- European Conditional Mouse Mutagenesis Program (EUCOMM) (Europe)
- EUCOMM: Tools for Functional Annotation of the Mouse Genome (EUCOMMTOOLS) (Europe)
- North American Conditional Mouse Mutagenesis Project (NorCOMM) (Canada)
- Texas A&M Institute for Genomic Medicine (TIGM) (USA)
Maintenance and Funding
- International Knockout Mouse Consortium Data Coordination Center (I-DCC) supported by the European Union (Project number: 223592)
- Knockout Mouse Project Data Coordination Center (KOMP-DCC) supported by the National Institutes of Health (Grant number: NIH HG004074)
References:
- A conditional knockout resource for the genome-wide study of mouse gene function, Nature 2011, 474: 337-342
- The mouse genetics toolkit: revealing function and mechanism, Genome Biology 2011, 12:224
- A Mouse for All Reasons, Cell 2007, 128: 9-13 (commentary)
- A New Partner for the International Knockout Mouse Consortium, Cell 2007, 129: 235 (commentary)
- Agouti C57BL/6N embryonic stem cells for mouse genetic resources, Nature Methods 2009, 6: 493-495